INFLAMMATION. 377 



duce trifling changes, while, if cartilage and bone be injured 

 simultaneously, very marked changes occur at once in the car- 

 tilage tissue, indicates a direct dependence of inflammatory 

 changes on blood-vessels. The rapid deposition of lime-salts in 

 the latter case can scarcely take place from any other source 

 than from a liquid introduced into the cartilage corpuscles. 

 Upon boring into the cartilage and the bone, lime-salts are 

 deposited in the basis-substance of the cartilage, at the border 

 of the perforation, in a zone which broadens as it approaches 

 the bone. This proves that the aperture is inundated with a 

 liquid, flowing from the blood-vessels of the injured bone, from 

 which the living matter of the cartilage derives the lime, origi- 

 nally kept in solution, ultimately to be deposited in the chondro- 

 genous basis-substance. 



Neither the sum of facts so far known to occur in inflamma- 

 tion of cartilage, nor the observations in keratitis, furnish any 

 foundation for overthrowing the theory of exudation, and of the 

 participation of the blood and the blood-vessels in the inflamma- 

 tory process. 



As regards the changes of the assumed " individuals/' the 

 u cells," this is a different matter. 



Strieker was the first who positively declared that the cells 

 by inflammation are reduced to a juvenile condition, in which 

 they are enabled to proliferate. This assertion was based upon 

 the observation of the changes which take place in the " proto- 

 plasmic body" namely, its swelling, its becoming amoeboid, the 

 formation of new nuclei and new corpuscles from the older ones, 

 and also the wasting of the " intercellular substance." 



This view, with all that it involves, can be maintained, not 

 only so far as the cells are concerned, but also for the inflamed 

 tissue in general. Every tissue, by the inflammatory process, is 

 reduced to the condition in which it existed in the first stage of its 

 development that is to say, to a condition corresponding to its. 

 embryonal state. 



Thus bone-tissue, in inflammation, is dissolved into the ele- 

 ments from which it originated. Through the dissolution of the 

 basis-substance medullary spaces are formed in the bone, at cer- 

 tain distances, which give to the inflamed bone of an animal, no 

 matter how old, the appearances found in a newly born individ- 

 ual. In addition to this, in inflammation the basis-substance 

 loses its lamellated structure, and in part assumes a striated 

 aspect, which again corresponds to the bone of a new-born 



