378 IN FLA MM A TION. 



animal. Finally, the medullary spaces are filled with elements 

 identical to those from which bone-tissue originated. 



The same is the case with periosteum and cartilage. The 

 periostea! ribbons, whose boundaries remain marked by un- 

 changed " elastic fibers/' are dissolved and form rows and groups 

 of globular and fusiform corpuscles, which correspond with the 

 original formers of periosteum, not only as regards their shape, 

 but in every particular. By inflammation cartilage is transformed 

 into medullary elements, such as originally composed its tissue. 



The totality of the elements observed in the inflammatory 

 process has been designated by the terms " inflammatory new 

 formation," " granulation tissue/' and " suppuration. " Recently, 

 every newly appearing element was termed simply a " pus-cor- 

 puscle." 



My own observations prove that the newly appearing elements 

 at first are nothing but the elements of the tissue themselves. 

 The term "inflammatory new formation" is applicable only in 

 the later stages of the inflammation, when really newly produced 

 corpuscles have originated from the freed mass of living matter. 



The designation " granulation tissue " is scarcely tenable for 

 the earliest stages of the inflammation, inasmuch as there is no 

 new tissue produced, but only a formation analogous to that 

 from which the inflamed tissue sprang that is, a medullary 

 tissue-formation for periosteum, cartilage, and bone. 



The general designation of " inflammatory new formation," 

 applied to " suppuration" or u formation of pus-corpuscles," is 

 decidedly incorrect. The results of my researches show that the 

 newly appearing, as well as the newly formed, elements are con- 

 nected uninterruptedly by filaments of living matter, both with 

 each other and with the non-inflamed neighboring tissue. 



If in inflammation of a tissue single corpuscles become sepa- 

 rated from their neighbors, and the so-called " migrating cells" are 

 produced, their locomotion is evidently only a transient action. 

 The newly formed red blood-corpuscles lying within their newly 

 formed vessels, and which in a later stage join the older vessels, 

 are really separated from the parent soil. 



Pus-corpuscles, on the contrary, are unquestionably isolated 

 elements which are separated from each other by a liquid. Pus, 

 however, is no tissue, and from it, so far as we know and it is 

 generally admitted, new tissue will never arise. 



There is a marked difference, therefore, between those proc- 

 esses which pathologists have termed "plastic inflammation," on 



