INFLAMMATION. 379 



the one hand, and " suppuratiee inflammation" on the other; al- 

 though it may be granted that these processes depend only on 

 different degrees of irritation. 



Let us consider the inflammatory changes of the living matter 

 of the tissue-units. In inflammation, this matter is probably at 

 first provided with a surplus of liquid nourishing material. The 

 question whether this material is conveyed in spaces between the 

 living matter and the basis-substance, or whether the liquid im- 

 mediately enters the living matter, i. e., is imbibed by it cannot 

 be answered by direct observation. This fact, nevertheless, is 

 certain, that the surplus nourishing liquid shows its effects gen- 

 erally in the youngest portion of the tissue-unit viz.: in the 

 nucleolus and the nucleus of the non-infiltrated corpuscle. This 

 portion is usually the first to return to the juvenile condition ; 

 it is divided into a number of particles, as has been stated by 

 Virchow. 



The living matter inclosed in the basis substance, upon 

 receiving the increased nourishing material, responds, as a rule, 

 by a dissolution of its basis-substance. Next follows the reestab- 

 lishment of the juvenile condition in a certain number of centers, 

 each of which represents a nucleus or a nucleolus ; and thus the 

 embryonal or juvenile stage of the tissue, as described above, is 

 re-assumed. Nearer the inflammatory focus the recurrence of 

 youth is established in a larger amount of living matter, which is 

 transformed into compact masses. Each mass may divide, and 

 each fraction may give rise to a new corpuscle. If the connec- 

 tion between these corpuscles remains intact, medullary tissue is 

 the result ; if, on the contrary, the connection is broken, the com- 

 pact particles of living matter are hcematoMasts, and, eventually, 

 red blood-corpuscles. 



The formation of new elements from larger masses of living 

 matter, as can be directly proved, is accomplished in such a way 

 that within these masses, at certain intervals, new boundaries 

 arise, the so-called " marks of division," which depend upon the 

 location of the compact centers. These boundaries are newly 

 formed cement- or basis-substance, in which there are no reticular 

 formations, but merely delicate spokes of living matter. Every 

 newly formed inflammatory corpuscle corresponds to a central 

 body, whose living matter retains its embryonal condition 

 viz. : to a nucleus or to several nucleoli. 



Lastly, if in many places the connection of living matter be 

 broken, i. e., the spokes uniting the single lumps be torn, the 



