386 INFLAMMATION. 



tion had pervaded a large amount of the newly formed cartilage, 

 while in other places the formation of medullary spaces and of 

 trabeculae of bone was observed the latter, however, only on a 

 small scale. 



Simultaneously with the deposition of lime-salts, and often 

 independently of it, a peculiar change is observed, at nearly reg- 

 ular intervals, in certain points of the cartilage tissue viz. : the 

 formation of red blood-corpuscles, of blood-vessels, and also of 

 medullary tissue. Those portions of the cartilage tissue which 

 exhibit, in the basis-substance, at an earlier stage, the greatest 

 number of small bioplasson lumps, and which have, to all appear- 

 ance, sprung from former capillary blood-vessels, show the most 

 marked new formations of blood and blood-vessels. 



Nests of medullary or indifferent corpuscles, or multinuclear 

 bioplasson masses, are found, exhibiting an active outgrowth of 

 living matter. This divides into small lumps, which subsequently 

 imbibe haemoglobin, and constitute, first, haematoblasts and, later, 

 red blood-corpuscles (see page 98). The peripheral portions of 

 the plastids, or the multinuclear masses, are changed into flat, 

 thickened layers of bioplasson, which lay the foundation of the 

 walls of blood-vessels. Such a wall, in the optical section, exhib- 

 its slight fusiform thickenings, indicating, perhaps, the future 

 nuclei of the endothelia. Club- and rosette-shaped formations of 

 this kind are at first connected with older blood-vessels by means 

 of solid, bright cords of living matter, which, after they are hol- 

 lowed out, establish a communication between the newly formed 

 blood-vessels and the older ones. (See Fig. 163.) 



Together with the appearance of blood-corpuscles and blood- 

 vessels, and the deposition of lime-salts in the basis-substance of 

 the cartilage ( u osteoid tissue" of authors), the new formation of 

 medullary spaces is inaugurated. Around the newly formed 

 blood-vessels, or independently of them, the cartilage tissue 

 breaks down into medullary elements, solely in consequence of a 

 dissolution or liquefaction of the basis-substance. The newly 

 appearing medullary corpuscles are the same which, at an earlier 

 date in the healing process of the fracture, produced the cartilage 

 tissue. 



By a continuous dissolution of the calcified basis-substance, 

 the medullary spaces are enlarged and the medullary cor- 

 puscles augmented by a growth of living matter. In the cen- 

 tral portions of the medullary space the corpuscles produce 

 new blood-vessels, if such had not previously formed. The 



