404 INFLAMMATION. 



being present in the middle of every muscle-fiber as well as at its 

 periphery, in both situations clusters of nuclei are found, some 

 of which have originated from former nuclei, while others are 

 newly formed. A division and multiplication of the nuclei is 

 inferred from the fact that we frequently find clusters of nuclei, 

 exhibiting cleavage, or marks of division. 



The next change is that, by an increase of the bioplasson of the 

 sarcous elements, solid lumps arise, which in turn are split into a 

 reticulum and become nucleated, by the usual process of formation 

 of reticular from solid bioplasson. Thus medullary or inflamma- 

 tory corpuscles become visible, arranged in clusters, which are 

 unquestionably identical with those embryonal formations from 

 which the striated muscle-tissue is developed. Instead of clus- 

 ters of medullary corpuscles, sometimes multinuclear bioplasson 

 masses are observed. These clusters are separated from each 

 other by rims broader than those between the single medullary 

 elements ; but all of these and all of the clusters remain uninter- 

 ruptedly connected by means of delicate bioplasson filaments 

 which traverse the interlyingjight rims. (See Fig. 170.) 



The clusters are arranged in rows, indicating that at first the 

 sarcolemma remains unaltered. Afterward, however, it becomes 

 liquefied, and the inflammatory corpuscles sprung from the 

 muscle-tissue commingle with those produced by the peri- 

 mysium, and in this manner more or less extensive masses of 

 inflammatory corpuscles are formed, which are bounded by 

 relatively little changed muscle-fibers. 



A second change of the muscle-tissue consists in an enormous 

 increase of the bioplasson of the sarcous elements, which, by 

 confluence, produce irregular, caky, and globular masses of a 

 high degree of luster, apparently destitute of structure and closely 

 resembling fat. Former observers mistook these formations for 

 the result of a degenerative process. According to Spina's view, 

 which is undoubtedly correct, they are the products of a progress- 

 ive inflammatory change of the contractile muscle-tissue. 



These formations are not soluble in turpentine, therefore are 

 not fat j they are readily stained with chloride of gold, but not 

 with carmine. Evidently, they are solid lumps of bioplasson in 

 a juvenile condition, which, in 1872, I termed " haamatoblastic." 

 From them originate, by division, a number of small solid parti- 

 cles, each of which gives rise to a new inflammatory element, or, 

 should the lumps break apart and become isolated, to red blood- 

 corpuscles. Such corpuscles are often found in clusters within 



