422 INFLAMMATION. 



mation a large number of capillary blood-vessels are destroyed i. e., 

 transformed into the inflammatory new formation. Should the 

 inflammatory corpuscles separate and produce pus, a permanent 

 destruction of the vessels ensues. If, on the contrary, the in- 

 flammation should not pass the stage of tissue-formation, i. e., 

 become plastic and formative, an active new formation of blood- 

 vessels in the middle of the inflamed tissue will follow, independ- 

 ently of the former and older blood-vessels, and to an extent far 

 exceeding the former vascularity. Most of these newly formed 

 blood-vessels contain newly formed red blood-corpuscles. The 

 manner of new formation of blood and blood-vessels is dwelt 

 upon on page 373. Should new formation of blood-vessels in an 

 inflamed tissue not take place, the tissue will represent what is 

 termed a " tubercle, 7 ' and undergo different secondary changes. 



The endogenous new formation of elements within the epi- 

 thelia was first maintained by Remak in physiological, and after- 

 ward by Buhl, Rindfleisch, and others in pathological, conditions, 

 and its existence thoroughly proved by L. Oser. In opposition 

 to the view that the corpuscles visible in the endothelia had 

 immigrated from without, Oser demonstrated the origin of in- 

 flammatory corpuscles within the epithelia. My own researches 

 fully corroborate the statements of Oser. 



VARIETIES OF INFLAMMATION. 



From my statements it follows that I consider the presence of 

 blood-vessels to be a requisite for the production of an inflam- 

 matory process. As only connective tissue is supplied with 

 blood-vessels, it necessarily follows that the primary seat of 

 inflammation must always be in the connective tissue, and that 

 the structural changes of muscles, nerves, and epithelia are sec- 

 ondary to, though, perhaps, almost simultaneous with, those of 

 the connective tissue. An independent inflammation of epithelia 

 never occurs. I, therefore, consider the terms of " interstitial, 7 ' 

 " parenchymatous," etc., inflammation as superfluous, except for 

 clinical purposes. 



Emigration of colorless blood-corpuscles unquestionably oc- 

 curs, even in the earliest stages of inflammation, probably pre- 

 ceding structural tissue changes. Such an emigration may also 

 participate in the formation of pus-corpuscles, so long as the 

 blood-vessels are not destroyed. The principal change, however, 



