432 INFLAMMATION. 



could be traced from the pia mater, especially in the sulci between the con- 

 volutions, through the external gray and granular layers into the white sub- 

 stance, profusely branching and ramifying, and almost invariably engorged 

 with blood. In numerous places there were ramifications closely resembling 

 those of the capillaries, with sharp, well-defined, fluting outlines, colorless, 

 and of a high refractive power. Such groups were found principally in the 

 granular layer, but extended somewhat into the contiguous layers. There 

 were also numerous isolated, highly refracting bodies, scattered throughout 

 the whole cerebellum, but mainly in the granular layer. With a higher power 

 of the microscope, peculiar changes of the capillaries were shown, first 

 described by C. Wedl namely, the capillaries were transformed into either 

 single or double rows of brilliant, colorless globules, or completely trans- 

 formed into a glistening rod-like mass, with fluting outlines, and numerous, 

 partly, pedunculated, buds. The large isolated bodies had all the character- 

 istics of the corpora amylacea namely, they were concentrically striated 

 and umbilicated. In some instances, the umbilicus was found in direct union 

 with capillaries, which had undergone the above described changes. Excep- 

 tionally, I found the " cells of Purkinje," with their offshoots, presenting the 

 same glistening, highly refractive, appearance as the capillaries and corpora- 

 amylacea. Some of the latter looked as if they were composed of a number 

 of shining globules, closely packed together, the outlines of the globules 

 being just traceable within the clusters. 



I used the following re-agents: Carmine (both ammonia and alum solu- 

 tions), which stained the tissues, but left the globules colorless. Iodine (both 

 tincture and aqueous solution, both with and without sulphuric acid) ; the 

 result was unsatisfactory, for only once, after the use of the aqueous solution, 

 did I perceive any change in the globular bodies, and then the pale blue tint 

 was very indistinct, and only a few of the bodies affected. Hcematoxylon pro- 

 duced a distinct violet upon the tissues and the blood-vessels, while the glob- 

 ules were little affected, if any, by it. Chloride of gold (one-half per cent, 

 solution) made the outlines more distinct, but did not change the color of the 

 globules. Violet methylaniline stained the granular layer a deep blue, the 

 external gray layers and the white substance a dirty grayish-blue ; the 

 blood-vessels both in the normal and pathological condition were unaffected. 

 Fuchsine produced a pink stain in the gray layers ; the globular bodies and 

 blood-vessels were untouched. Osmic acid (one per cent, solution) pro- 

 duced a marked brown discoloration on the globules, but by no means as 

 deep as that we are accustomed to see on fat-globules. Picro-indigo gave 

 the blood-vessels and globules a bright green color, while the surrounding 

 tissues were of a much paler tint of green. 



In unstained specimens, the refractive power of the globules and corpora, 

 amylacea was so characteristic as to allow of no diagnosis, except calcareous 

 degeneration of capillaries, of corpora amylacea, and exceptionally of " cells 

 of Purkinje." In the whole list of my re-agents there was nothing found con- 

 tradictory to this, though, I must admit, very little to confirm it. The capil- 

 lary blood-vessels in several instances showed rows of calcareous globules on 

 both walls, while in the center a row of blood-corpuscles was still recognizable 

 in that portion of the capillary nearest the pia mater, while the central end of 

 the capillary was completely filled with the shining globules. The change, 

 therefore, which led to the formation of these globules must have taken place 

 in the walls of the capillaries, and in turn has led to the consolidation of the 

 entire blood-vessel. 



