460 TUBEBCULOSIS, 



supported the views held by Kokitansky, in opposition to the 

 plasma theory of Schwann and the cell-proliferation of Virchow. 

 The substratum of the inflammatory new formation, the out- 

 growth of connective tissue, is the whole of the living matter of a 

 living tissue. 



This process, as before mentioned, is constantly accompanied 

 by a new formation of red blood-corpuscles and also of blood- 

 vessels, due to a new formation of living matter. This occurs in 

 all tissues formed from the middle germinal layer, which from 

 their very origin are supplied with blood and blood-vessels. 



The result 'of these processes is the formation of a new tissue, 

 which simultaneously becomes vascularized, such as granulations, 

 vegetations, pseudo-membranes, etc. Virchow is satisfied in the 

 belief that a " tissue " is a mere accumulation of " cells " ; while I 

 have proved that we are justified in applying the term " tissue " 

 only when the elements are in a continuous living connection. 

 Isolation of the elements produces pus; pus is not a tissue, and 

 not endowed with the capacity for forming a tissue. 



The fact has been known a long time that inflammation may 

 exhibit marked differences, both in its course and in its termina- 

 tions. " Acute" and " chronic," "sthenic" and "asthenic," " plas- 

 tic" and " suppurative" inflammation are expressions common to 

 all clinicians. One of the most striking differences in the course 

 of inflammation was based upon the circumstance that, in some 

 instances, the disturbance is mainly confined to the vascular sys- 

 tem, in others it mainly appears in the inflamed tissue itself. One 

 of the main supports of the theory of the cellular pathology was 

 that the phenomena of vascular disturbance, nay, the blood-ves- 

 sels themselves, might be absent, f. L, in the cornea or the car- 

 tilage, and, notwithstanding, the tissue could become inflamed. 

 A new formation of " cells," even suppuration, might occur in 

 such tissues, these results being sufficient for the diagnosis of an 

 inflamed tissue. The essential feature of inflammation was the 

 new formation of " cells." To-day, things are different. With us, 

 a new formation of " cells "means a new formation of living 

 matter, and we are satisfied that blood and blood-vessels are 

 requisite to set up an inflammation. We know, besides, that in 

 inflammation a number of blood-vessels perish, their hollow bio- 

 plasson becomes solid and is immediately appropriated for the 

 new formation of tissue; while a simultaneous formation of 

 blood-vessels is going on by the hollowing and vacuolation of 

 originally solid cords of living matter. 



