TUMORS. 



493 



sarcoma ; (d) giant-cell sarcoma, and (e) melanotic sarcoma. 

 Billroth added another variety, the alveolar sarcoma. In ana- 

 lyzing the different varieties of myeloma, we are satisfied that 

 there are but two principal forms, which I propose to term 

 (a) globo-myeloma, corresponding to Virchow's round-cell sar- 

 coma j and (~b) spindle-myeloma, corresponding to Virchow's 

 spindle-cell sarcoma. Both varieties are sometimes found in 

 one tumor. 



(A) Globo-myeloma is composed of medullary tissue, with 

 globular elements. (See page 147.) These contain single or double 

 nuclei, or they are divided into smaller plastids, evidently in the 

 mode of growth and multipli- 

 cation of the elements. Tum- 

 ors of this kind, as a rule, are 

 of a grayish-red or grayish- 

 yellow color, containing a com- 

 paratively small number of 

 blood-vessels. Its sub-varieties 

 are: 



(a) Globo-myeloma, composed 

 of large plastids (large round- 

 cell sarcoma). These are sepa- 

 rated from each other, either by 

 a narrow rim of cement-sub- 

 stance or by a delicate fibrous 

 reticulum 5 all elements, how- 

 ever, are connected by means of FIG. 

 delicate filaments. The nuclei 

 are large, and contain several 

 coarse granules nucleoli. (See 

 Fig. 191.) 



fbj Globo-myeloma, composed 

 of small plastids (small round- 

 cell sarcoma), the structure 

 closely resembling the so-called adenoid or lymph-tissue. A deli- 

 cate fibrous reticulum holds varying numbers of plastids, which 

 are mostly solid, having the appearance of lymph-corpuscles, 

 some being surrounded by a finely granular bioplasson. This 

 form represents the a lymphoma " or " lympho-sarcoma " of 

 authors. (See Fig. 192.) 



(c) Glioma or glio-sarcoma. Virchow applies the term " gli- 

 oma" to tumors arising from the connective-tissue formations 



191. GLOBO-MYELOMA, COM- 

 POSED OF LARGE PLASTIDS. FROM 

 THE INTERMUSCULAR TISSUE OF 

 THE FOREARM OF A WOMAN. 



The globular, slightly flattened corpuscles 

 are separated from each other by a scanty 

 basis- or cement-substance. C 1 , solid cord, 

 indicating a new formation or a retrogression 

 of a blood-vessel; (72, fully developed capil- 

 lary blood-vessel. Magnified 600 diameters. 



