TUMORS. 



495 



CF- 



medullary and myelomatous tissue is that, as a rule, in the latter 

 the bundles of the spindles are interlacing i. e., course in differ- 

 ent directions, like interlacing fibrous connective tissue. Some- 

 times, however, the bundles take an almost parallel course, and 

 can be separated into radiating groups of spindles, the fascicular 

 spindle-myeloma (fascicular spindle-cell sarcoma of Virchow, fas- 

 cicular cancer of older patho- 

 logists). The sub-varieties of 

 spindle-myeloma are : 



(a) Spindle-myeloma, com- 

 posed of large plastids. These 

 are separated from each other 

 by a light rim of cement-sub- 

 stance or a delicate fibrous re- 

 ticulum, most distinct in trans- 

 verse sections of the bundles. 

 The nuclei of the spindles, as 

 a rule, are seen as homogen- 

 eous and shining lumps, often 

 exhibiting marks of division 

 and multiplication. Between 

 the nucleated spindles there 

 are fusiform fields, containing 

 a finely granular or homogen- 

 eous mass; this indicates an 

 approach to basis-substance. 

 (See Fig. 194.) 



(~b) Spindle-myeloma, composed of small plastids, either interlac- 

 ing or taking an exclusively parallel course. In many instances this 

 tissue bears a close resemblance to non-medullated nerve-fibers. 

 Evidently, tumors composed of such delicate spindles are often 

 mistaken for true new formations of nerve-fibers, a neuroma. 

 This variety of myeloma is not of infrequent occurrence in the 

 choroid, and often contains clusters of pigment which previously 

 belonged to the choroid or to the layer of pigmented endothelium 

 of the retina. Such pigment clusters, however, unless present in 

 a large number, will not justify a diagnosis of a melanotic mye- 

 loma. (See Fig. 195.) 



(c) Spindle-net myeloma (net-cell sarcoma of Virchow). In 

 this variety spindles of varying sizes branch at acute angles, unite 

 and form a reticulum. The meshes of the reticulum are elongated, 

 and hold a slight amount of basis-substance and globular or 



FlG. 193. GrLIOMA FROM THE ORBIT. 



RECURRENT TUMOR AFTER THE 

 ENUCLEATION OF THE EYEBALL FOR 

 GLIOMA OF THE RETINA. 



M, glioma element with several nuclei ; MS, 

 group of glioma elements, sprung from divi- 

 sion ; GC, fully developed glioma element ; CF, 

 spindle-shaped fibers between the groups of 

 glioma elements ; E, capillary blood-vessel. 

 Magnified 600 diameters. 



