TUMORS. . 507 



mass of pigment has disappeared, perhaps by interference with the nutrition of 

 the granules themselves, which have not yet been entirely deprived of vitality. 

 Thus the epithelium containing pigment is changed directly into indifferent 

 bioplasson bodies, from which, in turn, new elements arise. A real new 

 formation has as yet not taken place, but out of specific elements indifferent 

 ones have been produced by the formation of new separating lines of cement- 

 substance. (See Fig. 204.) 



Of particular interest is the condition of the hair-follicles and sweat-glands 

 which are imbedded in the tumor. Many hair-follicles, still holding hairs, 

 presented no material change ; in others, the hair was wanting and the con- 

 nective tissue of the follicle was transformed, in part at least, into the tissue 

 of the tumor. The elements of the outer root-sheath were divided into 



FIG. 205. SURFACE OF A MYELOMA IN THE EIGHT GROIN 

 OF AN ADULT. 



M, partial wasting of cement-substance ; P, thickened spokes (prickles) ; Si, spindle- 

 shaped plastids replacing the cement-substance ; S 2 , transition of the spindles into the frame 

 of the myeloma tissue. Magnified 600 diameters. 



glistening, brownish-yellow lumps, whose groupings indicated their origin 

 from epithelia. All these bodies were interconnected by fine filaments. The 

 ducts of the sweat-glands remained unaffected in most instances; but the 

 glands presented a conglomeration of bright-yellowish bodies, which by their 

 clustered arrangement indicated their origin from glandular epithelia. In many 

 tubules seen in transverse sections the central caliber was absent, and in some 

 places the bounding (structureless) layer of connective tissue was also gone, 

 and the tissue of the tumor came in direct contact with the changed epithelia. 



