508 



TUMOES. 



The skin covering the tumor (2) gave no evidence of ulceration, but was 

 merely stretched, attenuated, and reddened. In vertical sections peculiar 

 changes were noticed in the epidermal layer, which was reduced to a few layers 

 of epithelia of the rete mucosum. Near the surface several epithelia were 

 found coalesced, owing to the entire disappearance of the separating cement- 

 substance. The "prickles" traversing the lines of cement-substance were 

 well marked, even enlarged into oblong or square granules. In other places, 

 instead of these granules, spindle-shaped or oblong bodies were seen, repre- 



FIG. 206. GLOBO-MYELOMA, COMPOSED OF SMALL PLASTIDS. 

 VERSE SECTION OF A SEMINIFEROUS TUBULE. 



TRANS- 



E, unchanged columnar epithelia; ES, commencing transformation of epithelia into 

 myeloma elements ; 8, completed .transformation of epithelia into myeloma elements ; L, 

 caliber of the seminiferous tubule. (For low amplification of the same tumor see Fig. 192.) 

 Magnified 800 diameters. 



senting what Biesiadecki termed " migrating cells." Careful observation, 

 however, revealed that all of these bodies were connected with the neighbor- 

 ing epithelial elements by means of delicate filaments. Such formations were 

 particularly numerous along the border separating the epithelia from the 



