510 TUMOES. 



must be pronounced myelomatous alveolar formations, separated from each 

 other by scanty connective tissue. Here, also, the endogenous production of 

 living matter in liver-epithelia had led to the formation of myeloma tissue. 

 The brownish color of the liver epithelium gradually faded into the grayish- 

 yellow of the myeloma nodules. In like manner, the gradual transformation 

 was indicated by the degree of carmine-staining, which had no effect upon 

 unchanged liver epithelium, but became more intense with the deviation of 

 the newly formed tissue from normal type of epithelium. 



I can add that the myeloma of the submaxillary gland (4) presented, in 

 some portions, analogous appearances. In this tumor, too, the transforma- 

 tion of the epithelium of the acini of the salivary gland could be traced, step 

 by step. 



My researches, in brief, gave the following results : 



The myeloma growth, in its progress toward the epidermis, produces a change 

 in the living portion of the epithelium similar to that which is observed in the 

 superficial inflammatory processes of the skin. The cement-substance is dissolved ; 

 multinuclear bioplasson bodies arise, and in them new lines of division originate, 

 producing indifferent elements, resembling those which spring from connective tissue. 

 New elements are also produced by a new formation of living matter, both within 

 the epithelia and in their cement-substance investment ; in the latter situation, of 

 course, from the filaments or "prickles" of living matter. Such a new formation 



FIG. 207. SECONDARY MYELOMA OF THE LIVER. 



C, connective tissue which separates the myeloma nodule from the liver-tissue ; E, little 

 changed liver-epithelia within the myeloma nodule ; S, new formation of myeloma elements 

 from liver-epithelia ; P, remnants of portal vessels. Magnified 600 diameters. 



occurs in the epithelia of the external root-sheath and of the sweat-glands. The 

 attenuation of the epidermis is evidently caused by a gradual transformation of the 

 epithelia of the rete mucosum into myeloma tissue. In myelomata of glandular 

 organs, salivary glands, testes, liver, the new formation of bioplasson starts in 

 the epithelia with the appearance of new marks of division, and newly formed mye- 

 loma elements. The living matter of epithelium is directly converted into myeloma 

 tissue, with a partial or complete destruction of the epithelia. 



