TUMORS. 



541 



mations, filled with a continuous layer of bioplasson, with nuclei imbedded at 

 regular intervals. In such layers analogous to the so-called myeloplaxes 

 the cement-substance was partly or totally absent. A striking feature was 

 that, in tumors of slow growth, the epithelia were small and their granules 

 and lumps of bioplasson minute ; while in cancers of rapid growth the epithe- 

 lia contained coarse granules and large nucleoli. In the cancer of the liver, 

 which had increased rather rapidly, the epithelia exhibited a very coarse 

 granulation, and both within and between them were seen numerous lumps 

 of a homogeneous appearance, without a reticular structure. Many of these 

 lumps in the alveoli had no similarity whatever with true epithelial bodies. 



The second constituent part of the cancer tumors i. e., the connective 

 tissue especially in those of comparatively rapid growth, exhibited the so- 

 called " small cellular infiltration." (See Fig. 225.) 



,1 



FIG. 225. CANCER OF THE SKIN OF THE PAROTID REGION. 



A, alveolus filled with epithelia; L, so-called "small cellular" infiltration of the con- 

 nective tissue ; E, formations within the connective tissue resembling epithelia ; V, blood- 

 vessel in transverse section. Magnified 600 diameters. 



Examination with the highest powers of the microscope proved that this in- 

 filtration consisted of an accumulation of bright, globular homogeneous lumps, 

 on an average not reaching the size of red blood-corpuscles. Each lump was 

 almost constantly surrounded by a layer of bioplasson, whose granules .were 

 connected with the lumps by means of radiating filaments. The lumps 

 assumed a violet stain after treatment with chloride of gold. They exhibited 

 all phases of development, from compact masses to those which were pierced 

 with vacuoles, and finally tp those showing nuclei, which were inclosed by a 

 thin shell and contained one or two nucleoli. Evidently these were bioplasson 



