TUMOES. 547 



globular or oblong nuclei, which evidently are newly formed and have noth- 

 ing to do with the original nuclei of the lymph-corpuscles. I have shown (see 

 page 108, Fig. 31) that the myxomatous reticulum holds a delicate net-work 

 of living matter, which, by the liquefaction of the basis-substance held in its 

 meshes, becomes freed. This, most probably, is the process through which 

 the myxomatous frame-work is converted into the same mass as the corpus- 

 cles. These masses are coarsely granular, which means that they are freely 

 supplied with living matter. 



The next stage is the appearance of cement-substance in the shape of 

 straight, light lines, arising first in the middle of the bioplasson between the 

 nuclei. At first, the cement-lines are scarce and in many places traversed by 

 broad bridges of bioplasson. Later, the cement-substance assumes a regular 

 polyhedral shape, though it is always pierced by delicate spokes of living 

 matter, which are the inosculations of the reticula of living matter contained 

 by the neighboring epithelia. 



The last feature is the formation of a frame of connective tissue which 

 divides the large bioplasson layer into smaller alveoli the cancer nests. 

 The first trace of this formation is the appearance of delicate nucleated 

 spindles, which, by being split into smaller ones, build up the fibrous 

 basis-substance. At the same time the blood-vessels of these trabeculse 

 are formed. 



Not infrequently the cancer nests in the middle of lymph-ganglia exhibit 

 concentric onion-like layers of epithelia, which in all probability arise from 

 the pressure caused by the contraction of the surrounding connective tissue. 

 In the center of a nest we often see epithelia undergoing fatty degeneration. 

 Sometimes this has advanced to such an extent as to form a fat plug, which 

 is always surrounded by flattened horny epithelia. I found this concentric 

 arrangement in the first three cases. The fourth exhibited a fibrous frame 

 inclosing irregular alveoli, filled with large and coarsely granular epithelia 

 without any regularity. 



The essential point in the invasion of lymph-ganglia by cancer is, first, the 

 melting together of their components into large bioplasson masses. These in 

 turn, by the formation of a cement-substance, are split up into polygons, 

 which in groups become ensheathed by vascularized connective tissue, and 

 thus give rise to the cancer nests. 



The study of the last case, that of a rapidly growing primary cancer of 

 the foot, forced me to the conclusion that the same changes take place in the 

 formation of cancers in general. For along the edge of the fully formed car- 

 cinomatous tissue I found all the changes that I have just described. In this 

 specimen, the infiltration of the normal tissues with globular corpuscles was 

 unusually well marked. No doubt, the infiltration is itself a part of the can- 

 cerous metamorphosis, and it is only one of the steps of the adult tissue 

 toward a complete transformation into cancer tissue. So far as the micro- 

 scope can prove, this infiltration in its histological appearance is identical 

 with adenoid tissue, and the globular corpuscles are identical with the lymph- 

 corpuscles. In their retrograde change there is but one step toward the for- 

 mation of multinuclear masses. 





Secondary Changes of Cancer. Both the constituent tissues of 

 cancer often undergo changes, which may either invade the 



