THE LIVEE. 



689 



where the inflammation has reached a high degree, the lobules are reduced to 

 less than a third of their normal diameter, and, unquestionably, many of 

 them perish altogether. The boundary between the decreased lobules and the 

 surrounding tissue is not everywhere sharply marked, inasmuch as formations 

 characterized by a brownish color penetrate the interstitial tissue to varying 

 depths, indicating that a transition of one kind of tissue into the other is tak- 

 ing place. We also notice that the liver epithelia are no longer arranged in 

 regular rows and tracts (this fact was known to former observers), but are 

 now clustered in groups or separated from each other by broad interstices. 

 (See Fig. 305.) 



In order to answer the query what are the changes that have led to such 

 a considerable wasting of the epithelia, we must examine places where there 





FIG. 306. BOUNDARY OF A LOBULE OF A CIRRHOTIC LIVER, 

 TOWARD THE INTERSTITIAL TISSUE. 



E, coalesced groups of liver epithelia, in part containing fat-globules ; M, medullary cor- 

 puscles sprung from liver epithelia ; C, interstitial connective tissue, with blood-vessels ; , 

 (Kiss-section of a bile-duct. Magnified 500 diameters. 



is 110 marked boundary between the epithelia and the interstitial tissue. 

 Here we see that in many places the cement-substance between the epithe- 

 lia is missing. A number of epithelia have coalesced into groups destitute 

 of cement-substance, or exhibiting only traces of it. Most of the gran- 

 ules of the epithelia are enlarged, many of them reaching the size of 



44 



