690 



THE LIVER. 



nucleoli ; others appear as nearly homogeneous, shining lumps of a brownish 

 tint. In this process of growth the granules of the nuclei also participate, 

 and, where before a nucleus was present, we often find coarse granules inter- 

 ' connected by filaments. Through the increased size of the granules and the 

 coalescence of neighboring epithelia, large, coarsely granular bodies arise, in 

 which, evidently by an outgrowth of some of the granules, new nuclei appear, 

 never attaining, however, the size of the original nuclei. (See Fig. 306.) 



In the next stage we observe marks of division appearing in the multi- 

 nuclear bodies, and thus various-shaped elements arise, which remain inter- 

 connected by delicate filaments traversing the light rims. They form the 



FIG. 307. BOUNDARY OF Two LOBULES OF A CIRRHOTIC LIVER 

 TOWARD THE INTERSTITIAL TISSUE. 



JE? 1 , coalesced liver epithelia; E*, multinuclear bodies, sprung from epithelia; M, medul- 

 lary corpuscles, the offspring of the epithelia ; J, interstitial connective tissue, holding blood- 

 vessels ; C, irregularly sinuous capillaries. Magnified 600 diameters. 



indifferent, medullary, embryonal, or granulation tissue, which still retains 

 the original brownish-yellow color of liver epithelia. As some of the cor- 

 puscles are infiltrated with basis-substance and others elongated into spindles, 

 they produce the so-called " young or unripe" connective tissue. The inter- 

 stitial tissue is, to a great extent, composed of these spindles. These forma- 

 tions, which with low powers of the microscope strongly resemble fibrillee 



