THE LIVEE. 



693 



A large number of the capillaries of the lobules are destroyed in the 

 process of cirrhosis; for injected specimens plainly demonstrate that the 

 calibers of most capillaries are considerably narrowed, and not permeable to 

 the injected gelatine. Other capillaries, on the contrary, are irregularly 

 widened (see Fig. 309). Thus we meet, besides capillary blood-vessels 

 engorged with blood, solid cords, which from their course must be consid- 

 ered as obliterated blood-vessels. 



FIG. 309. CIRRHOTIC LIVER. BLOOD-VESSELS INJECTED. 



M, multiiiuclear bodies, sprung from liver epithelia; F"*, partial transformation of an 

 epithelium into fat ; F l , f 3 , complete transformation of epithelia into fat; C l , C 2 , irregular 

 capillaries injected. Magnified 500 diameters. 



First, the vascular walls appear thickened and transformed into nearly 

 homogeneous, yellowish, shining tracts, in which the boundary lines of former 

 endothelia are no longer recognizable. This change causes a noticeable 

 narrowing of the caliber, while later the walls fuse together into a solid cord. 

 In such a cord a differentiation takes place into small medullary corpuscles, 

 analogous to those arising from the liver epithelia, and producing an increase 

 of connective tissue. In this manner numerous blood-vessels are obliterated 

 and perish. The interstitial connective tissue in cirrhosis of the liver is 

 known to be scantily supplied with blood-vessels. 



The results of my researches are the following : 



In the normal liver of man, cat, and rabbit, the glandular epithelia are 



