702 



THE LIVER. 



of the epithelia into fat-granules step by step. By their coales- 

 cence fat-globules originate, which replace the central portions 

 of the liver epithelia, including the nucleus, while, even in high 

 degrees of fatty degeneration, every epithelium still shows a 

 peripheral (sometimes very narrow) zone of unchanged reticular 

 bioplasson around the central fat-globule. Further studies are 

 required before positive statements can be made concerning the 

 nature and cause of fatty degeneration of the liver. 



Pigmentary degeneration is observed chiefly in livers of persons 



LE 



FIG. 314. SUPPURATIVE HEPATITIS IN PY^MIA. 



LE, unchanged liver epithelia; PC, capillary blood-vessels, containing blood- and pus- 

 corimscles; CE, epithelia (cancer-elements 1 ) in a capillary blood-vessel. Magnified 800 

 diameters. 



who had been for years affected with severe forms of so-called 

 malarial poisoning. In such livers I have found granules of a 

 dark brownish or black pigment, accumulated mostly in the epi- 

 thelia bordering the central hepatic vein, and some coloring 

 matter was also found, as a rule, in the neighborhood of the 

 portal vein. Our knowledge of the causes of the formation of 



