F. A. BAINBRIDGE AND H. H. DALE. 



inhibitory, or polyphasic, with a preponderance of motor effects very 

 similar to those described below as obtained in our own earlier experi- 

 ments. He concludes that the splanchnics contain both motor and 

 inhibitory fibres for the gall-bladder, deciding that the motor effect is 

 genuine on the ground that it can be obtained after bleeding the animal 

 to death. 



Our own earlier experiments on the effect of stimulating the 

 splanchnic nerves and of intravenous administration of adrenalin led to 

 conflicting results. In some cases we obtained a result apparently 

 identical with that of Doyon: in others we observed pure relaxation: 

 in others again we found mixed effects, di- or even triphasic curves being 



Fig. 3. 



Fig. 4. 



Fig. 3. x f|. Curare. Gall-bladder not separated from liver. Right splanchnic cut, the 

 peripheral end being placed on Ludwig electrodes. Blood-pressure from carotid. 

 At A stimulation of right splanchnic, coil at 3000 (Berne graduation). 



Fig. 4. x %\. Curare. Gall-bladder not separated from liver. At N 4 c.c. 1 in 50,000 

 adrenalin chloride intravenously. Usual rise of blood-pressure. 



produced. Figs. 3 and 4 show the apparently motor response to 

 sympathetic stimulation often obtained when the gall-bladder is left 

 in situ. 



Thinking that this variety of result was due to the presence of at 

 least two conflicting effects we attempted to determine which, if any, of 

 these were due to extraneous causes, and which to intrinsic movements 

 of the gall-bladder. We inserted between two adjacent lobes of the liver 

 a balloon exactly similar to that in the gall-bladder and similarly con- 



