144 



F. A. BAINBRIDOE AND H. H. DALE. 



nerve or intravenous injection of adrenalin. Fig. 5 shows the effect 

 of stimulating the right splanchnic after opening the chest wall and 

 slitting the diaphragm. Stimulation of the left splanchnic under such 

 conditions, if it produces any effect at all on the gall-bladder, merely 

 causes a small gradual increase in tone and rhythmic activity, such as 

 accompanies a rise of general blood- pressure from any cause (Fig. 6). 

 In Figs. 7 and 8 is shown the effect of adrenalin with the chest wall and 

 diaphragm intact, the difference produced by separating the gall-bladder 

 from the liver being clearly exhibited. It will be seen that the 

 relaxation, which in Fig. 7 appears as a mere preliminary dip in a curve 

 giving the impression of a predominantly motor effect, is shown in Fig. 8 

 to be the essential feature of the response to adrenalin. The pressure ex- 

 erted on the gall-bladder by the swelling of the liver is further illustrated 

 in both figures by the record obtained from the " artificial gall-bladder," 

 which simulates a contraction. Another feature of Figs. 5 and 8 has yet 



Fig. 5. Fig. 6. 



Fig. 5. x . Chest opened, diaphragm divided, phrenics cut. No curare. Eight 

 splanchnic dissected from the front, ligatured and cut above ligature. At B peripheral 

 end of right splanchnic stimulated with coil at 10 cm. 



Fig. 6. x J-J. Conditions as in Fig. 5. Left splanchnic dissected from the front: at D 

 the peripheral cut end of it stimulated with coil at 10 cm. The rise of b. -p. is accom- 

 panied by increase in tone of gall-bladder. (The point of the piston-lever not being 

 opposite that of the manometer float, there are two signal lines : the upper for the 

 gall-bladder, the lower for the blood-pressure.) 



