146 



F. A. BAINBHIDGE AND H. H. DALE. 



permanent improvement in the tone of the gall-bladder. A succeeding 

 dose of adrenalin caused in this case a further rise of blood-pressure and 

 a further increase in the tone of the gall-bladder. On the other hand, 

 under conditions which allow the sympathetic stimulation to occur 



Fig. 9. Fig. 10 



Fig. 9. x f|. Curare. Gall-bladder separated from liver. From the end of a long 

 experiment. Blood-pressure had become very low (20 mm.) ; so had the tone of gall- 

 bladder. At T 5 c.c. of 1 in 50,000 adrenalin intravenously. 



Fig. 10. x f|. Chest opened, diaphragm divided, phrenics cut. No curare. Vagi and 

 splanchnics cut. Blood-pressure from carotid. At H 1 c.c. 1 in 10,000 adrenalin 

 intravenously. 



without a large simultaneous rise of blood-pressure, the gall-bladder 

 responds by pure relaxation without any after-tone. For example, the 

 effect of adrenalin on the blood-pressure is greatly reduced by leaving the 

 vagi intact, or when, as is often the case, the heart is weakened by the 

 exposure entailed in opening the chest. Under either of these conditions 

 we have obtained pure relaxation of the gall-bladder in response to 

 adrenalin, without after-tone (Fig. 10). Again, when, by the admin- 

 istration of chrysotoxin 1 , the endings of motor sympathetic fibres are 



1 Of. Dale. Proc. Physiol. Soc. p. Iviii. 1905. (This Journal, xxxn.) 



