GALL BLADDER. 



147 



paralysed, adrenalin produces practically no effect on the blood-pressure. 

 Under these conditions the inhibition of the gall-bladder is very pro- 

 longed and quite uncomplicated by after-tone 1 (Fig. 11). 



Fig. 11. Fig. 12. 



Fig. 11. x \%. From same experiment as Fig. 9, after intravenous injections of sodium 

 cbrysotoxin amounting to 0-2 gm. in all. At W 1 c.c. of 1 in 10,000 adrenalin 

 intravenously. 



Fig. 12. x $. Conditions as in Fig. 5, but towards the end of an experiment, when 

 animal was moribund, and blood-pressure very low (20 mm.). At F peripheral end 

 of rt. splanchnic stimulated with coil at 8 cm. Blood-pressure rose to 40 mm. 



When, however, due allowance has been made for the undoubtedly 

 large part played by blood-pressure changes in producing these motor 

 effects, and when, further, the simulation of motor effects by changes 

 in liver-volume, which complicates the experiments of Doyon and of 

 Freese, has been definitely excluded, there remains a small residuum 

 of phenomena not satisfactorily accounted for. The difficulty, in fact, is 

 not dissimilar to that met with by various observers in dealing with the 

 effect of stimulating the splanchnics on the movements of the small 

 intestine 2 . 



When the tone of the gall-bladder and the blood-pressure have both 

 become low we have occasionally provoked a decided contraction by 



1 Here, however, the possibility must not be neglected of an admixture of motor fibres 

 in the sympathetic supply to the gall-bladder. Chrysotoxin would paralyse these. 



2 Cf. Bunch. This Journal, xxn. p. 357, 1898, who gives the literature of the 

 subject : also Bayliss and Starling. This Journal, xxiv. p. 99. 1899. 



