150 



F. A. BAINBRIDGE AND H. H. DALE. 



autonomic supply to produce its full effect. The intestine, for example, 

 after a large dose of chrysotoxin, responds more vigorously to stimulation 

 of the vagus than it does after section of the splanchnic nerves only. 

 We have found the same effect in the case of the gall-bladder. After a 

 large dose of chrysotoxin (0'2 gram or more for a medium-sized dog), 



Fig. 14. x \. From same experiment as Figs. 10 and 11. After 0-2 gm. chrysotoxin. 

 At T and U peripheral end of left vagus stimulated in the thorax with coil at 6 and 5 

 cm. Blood-pressure unaffected. 



Fig. 15. Fig. 16. 



Fig. 15. x ^f . Conditions as in Fig. 14. At (7 and D the left vagus stimulated peri- 

 pherally in the thorax, coil at 4 cm. Blood-pressure unaffected. 



Fig. 16. x |f . Conditions as in Figs. 14 and 15, with less sensitive recorder. 0'2 gm. 

 chrysotoxin given. At X 1 c.c. 1 in 10,000 adrenalin intravenously. At Y left vagus 

 stimulated peripherally in the thorax : coil at 3 cm. The effects of sympathetic and 

 vagus stimulation are contrasted. 



stimulation of either vagus nerve in the thorax always causes a distinct 

 augmentor effect on the gall-bladder, in which either increase of tone or 

 exaggeration of rhythm may be the predominant feature, whilst in other 

 cases, again, both may be simultaneously affected. In our experiments 



