and even basophil punctation, but there is no blue 

 protoplasm of a parasite. 



6. Skin Contaminations. Brownish yellow or 

 even black pigment from the skin should not be 

 confused with malarial pigment (melanin). Melanin 

 practically never occurs free in the blood, but always 

 in the protoplasm of leucocytes. Stained micrococci, 

 yeasts, etc., are not uncommon, especially in the 

 tropics. 



7. Squashed Leucocyte Nuclei. Frequently in 

 malaria films (stained) large open meshworks of nuclear 

 matter are seen with little or no surrounding proto- 

 plasm. These are degenerated or dropsical, or, 

 according to others, mechanically damaged leucocytes, 

 and often occur in great numbers. 



8. Deformed Red Cells. Further, we must point 

 out an extraordinary appearance of the red cells in 

 stained films. In anaemic (malarial) bloods we find 

 red cells ten, thirty, or forty times the diameter of a 

 normal cell, and these huge swollen structures shew at 

 one side a crescentic area which is granular, and is 

 the only remaining part of the red cell that can be 

 recognized ; the remainder is practically unstained. 

 These gigantic structures may or may not be occupied 

 by parasites. They are probably caused by the 

 spreading of the film. 



To DETERMINE THE SPECIES OF PARASITE PRESENT 



Three forms are recognized simple tertian, 

 malignant tertian, and quartan. The malignant 

 tertian can, as we shall see, produce a quotidian 

 temperature with only a single generation of parasites. 

 Whether or no there is a true quotidian parasite, one 

 or more, is extremely doubtful. 



