33 



(but it is difficult to get this staining effect) a charac- 

 teristic coarse stippling quite different from that of 

 the simple tertian. ^These consist of a few coarse dots 

 or clefts around the parasite (Plate I, fig. 4). 



The finding of crescents is, of course, diagnostic 

 of malignant tertian, bu't the possibility of a double 

 infection, e.g., simple and malignant tertian, must be 

 borne in mind. 



Simple Tertian. I. Characteristic is the fact that 

 the infected red cell is distinctly larger than usual. 



2. Characteristic also is the fact that the red cell; is 

 dotted all over with fine red granules (Schuffner's dots). 

 Young forms as well as old produce this change in the 

 red cell in a well-stained specimen, not overwashed. 



3. The young rings are larger and more flimsy- 

 looking than the previous. Pigment may be seen ; 

 it must be noted, however, that pigment is often 

 obscured by Romanowsky stains. 4. The large forms 

 are pigmented, irregular, flimsy-looking, and appear 

 often as if consisting of two separate parts. This 

 irregularity is characteristic (Plate I). 



Quartan. I. The red cell is unchanged. 2. The 

 rings. are compact, not irregular, and shew pigment 

 early, but the diagnosis of the species of young rings is 

 very difficult. 3. Larger forms are compact, and 

 characterized by the peculiar dense nature of the 

 chromatin, which is, relative to the size._of-the cell, 

 plentiful. 4. Pigment often occurs as a dense streak 

 along the margin. These parasites once seen are easily 

 recognized again (Plate I). 



We have so far described the forms generally 

 encountered during a febrile attack and the means of 

 making a diagnosis, but it is necessary to consider 

 other forms, e.g., the sporulating forms, and more 

 especially the gametes. 



