5 



2. There is a terminal infection with the 

 diplococcus pneumoniae. 



Spleen. The trabeculae of the pulp are distended 

 by infected red cells, and pigmented large mononu- 

 clears are abundant. The malpighian follicles, on the 

 contrary, are non-pigmented. 



Liver. Endothelium of capillaries is swollen and 

 pigmented. Pigment is also found in Kupfer's cells. 

 The liver cells contain only haemosiderin, not melanin. 

 Pigmentation is most intense around the central veins. 



,.4U -* f.*- 



Fig. 13. Shewing de-position of Pigment in Liver (left), 



Spleen (right), and Sporulating Parasites in 



Brain Capillary (bottom) 



Kidneys. Pigmentation is much less marked. 

 Changes may occur in the epithelium of the tubules, 

 independent of the presence of parasites. 



Bone Marrow. Parasites and melanin, free, and 

 in large mononuclear leucocytes, and macrophages are 

 found. Crescents may be found here when absent 

 of scanty elsewhere, as in the spleen and brain ; it is 

 consequently supposed that they principally develop 

 here. 



