In cases of malaria of long standing the yellow 

 marrow becomes red. 



Stomach, and Intestines. In malaria with choleraic 

 or haemorrhagic symptoms, parasites may abound in 

 the capillaries of the villi. 



CHRONIC MALARIA 



Spleen. As is well known, the spleen may in 

 these cases fill the whole abdomen. Dilatation of the 

 various lacunae occurs with a thickening of the splenic 

 reticulum. The pigment tends to become deposited 

 eventually in the connective tissue surrounding the 

 follicles. The splenic septa become thickened. 



Liver. The pigment is found mainly in the 

 periphery of the lobules, and pigment in the form of 

 blocks in the perivascular connective tissue. 



The capillaries are much dilated, and the epithe- 

 lium contains blocks of pigment. Atrophy of the liver 

 cells and their nuclei occurs. 



Bone Marrow. The marrow of the long bones 

 is usually red, due to a large development of haemato- 

 blastic tissue. Normoblasts are common. 



Pigment disappears rapidly from the bone marrow. 



LITERATURE 



Marchiafava and Bignami. Twentieth Century Practice of 

 Medicine. Malaria. Vol. XIX. S. Low, Marston and Co. This 

 comprehensive and learned treatise is incomparably the best in the 

 English language, dealing with all aspects of malaria and also black- 

 water fever. 



