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conditions, (i) in those cases where quinine has been 

 taken, (2) where consequently the diagnosis is uncertain 

 and the question of typhoid fever, etc., arises. 



TRYPANOSOMIASIS 



An increase in the large mononuclears has been 

 found in human trypanosomiasis, but it would appear 

 as if an increase in the lymphocytes were the character- 

 istic change in sleeping sickness. The possibility of 

 this should, therefore, be excluded by gland puncture. 



TYPHOID FEVER 



During the first week (of uncomplicated cases) 

 the leucocytes are normal. 



During the second week there is a leucopenia, 

 e.g., 2,000, and the leucopenia is in proportion to the 

 severity of the disease. 



During the third and fourth weeks the leucopenia 

 is still more marked, though also a leucocytosis may be 

 found without any apparent cause. 



Relative Leucocyte Values. During the third, 

 fourth, and fifth weeks the mononuclears, large and 

 small, may reach the values of forty to sixty per cent., 

 and among these the proportion of small mononuclears 

 is very striking. 



PNEUMONIA 



There is very early a leucocytosis, e.g., 25,000, 

 four hours after the initial chill. The maximum 

 occurs, as a rule, just before the crisis. The number 

 may fall from a high value to normal in twenty-four 

 hours. Leucocytosis is said to bear a relation to the 

 amount of exudation (i.e., lobes involved). 



