243 



leucocytes, as these, as also in ordinary malaria, may 

 require long search. 



10. Make careful differential counts of the 

 leucocytes, especially when the temperature is falling, 

 as it is then that the mononuclear increase is most 

 marked. When the temperature is raised (e.g., 103 

 to 105) the polynuclears may reach ninety per cent. 



n. Observe presence of normoblasts, megalo- 

 blasts, various abnormal staining reactions, e.g., poly- 

 chromasia of the red cell, especially during recovery. 



12. Make careful blood counts immediately 

 before and after administering quinine when no haemo- 

 globinuria results. According to Panse there may 

 result a blood destruction due to the quinine, which 

 does^not shew itself as haemoglobinuria. 



Microscopical investigations in this disease are 

 frequently negative as regards malaria parasites, but 

 it is all important when the examination is made, as 

 the following analysis of over one hundred cases 

 microscopically examined shows : 



