2 4 6 



Spleen. Malarial pigment (melanin) occurs in large mononuclear 

 cells and in giant cells (macrophages). Melanin may also occur in the 

 stroma or even beneath the capsule. 



Liver. Melanin occurs in endothelial cells, and especially in 

 macrophages. Yellow pigment (haemosiderin) occurs in the liver 

 cells, also, to a certain extent, in the same situations as melanin. Apply 

 the iron reaction (vide Appendix) to the sections. Haemosiderin 

 gives the blue colour, melanin does not. 



Kidney. Necrosis and desquamation of the epithelium of the 

 convoluted tubes. The straight tubules are blocked with masses of 

 granular matter, staining dark red with eosin. Interstitial nephritis 

 usually not present. 



Bone marrow. Evidence of malarial infection (pigment). Pro- 

 liferation of normoblasts (cp. p. 49). 



LITERATURE 



Twentieth Century Practice of Medicine. Malaria, by Marchiafave 

 and Bignami. The fullest and best account in the English language. 



Allbutt and Rolleston. Vol. II, pt. ii. Blackwater Fever, or 

 Osier's Modern Medicine. Vol. I. Blackwater Fever. 



