348 



(2) Period of c Plaques ' : In forty to fifty days 

 after coitus well defined areas as big as a shilling or 

 crown piece appear, representing angioneurotic 

 oedematous patches. These plaques last a week or so, 

 or may suddenly appear and again disappear. 



(3) Periods of paralysis and extreme anaemia : 

 Skin abscesses and eye symptoms occur. Paralysis of 

 the hind quarters develops, so that the animal cannot 

 stand. Death occurs in two to ten months or even 

 much later. Ruminants are refractory to inoculation. 



Blood Examination. Trypanosomes are found 

 only with great difficulty, but fairly easily in the area 

 of a plaque if examined at its first appearance. 



Morphology. 25-28^ long. The protoplasm does 

 not as in T. brucei contain chromatin granules, and the 

 posterior end is often slightly cleft. 



Transmission. Is effected by coitus of an infected 

 stallion with a mare or vice versa. The resemblance 

 to syphilis should be borne in mind. 



Pathology. The inguinal lymphatics and testes 

 are infiltrated and caseous. According to Mott, follow- 

 ing the primary sore there is inguinal gland enlargement, 

 then general gland enlargement. The virus is con- 

 veyed along the lymphatics of the pelvic plexus of 

 nerves to the lumbo-sacral ganglia primarily, and to all 

 the spinal ganglia eventually. This leads to the angio- 

 neurotic eruption (plaques) which may subside leaving 

 no trace, or it may end in patches of leukoplakia if the 

 inflammation be intense enough to destroy the 

 ganglion cells. Likewise secondary degeneration of 

 the posterior roots, causing an ataxic condition of the 

 hind legs, or a general neuritis may be associated and 

 cause paraplegia, i 



6. T. theileri. The cause of a disease in South 

 Africa known as gal-ziekte (gall sickness). A similar 



