374 



HISTOPLASMA CAPSULATA (Darling, 1906) 



\ This parasite was found in enormous numbers in 

 the tissues in a patient in Panama. 



The Lungs shewed a condition closely resembling 

 miliary tubercle but the nodules consist of broken 

 down alveoli containing epithelial cells distended with 

 parasites. 



The Liver is enlarged. The liver cells and 

 endothelium of the portal capillaries are invaded by 

 myriads of parasites. 



Fig. 114. Histoplasma capsulata : intracorpuscular forms from n 

 smear of lung tissue, and free forms expressed from the cells 



'The Spleen is enlarged ( x 3) and firm. It con- 

 tains many parasites. 



Lymphatic Glands. The mesenteric and splenic 

 glands are enlarged, and parasites occur in mononuclear 

 cells. 



The Parasite is about half the diameter of a red 

 cell. It is round or oval and is surrounded by a refrac- 

 tive rim. The parasite has a large and small staining 

 mass. It is mainly an intracellular parasite. Whether 

 it occurs in the blood is unknown. 



