SUBCUTANEOUS INOCULATION OF ANIMALS 235 



general conditions as possible. For the first week the rabbits 

 received each 100 grams of green food (cabbage and turnips) 

 daily, and the guinea-pigs 30 grams each of the same food. 

 During the second week this daily amount of food was 

 doubled; during the third week it was quadrupled; and for 

 the fourth and fifth weeks they each received an excess of 

 food daily, consisting of green vegetables and grains (oats 

 and corn). By reference to the charts sudden diurnal 

 fluctuations in weight will be observed that do not corre- 

 spond in all instances with scarcity or sufficiency of food. 

 With the rabbits there is a gradual loss of weight with the 

 smaller amounts of food, which losses are not totally re- 

 covered as the food is increased. With the guinea-pigs there 

 is likewise at first a loss; but after a short time the weight 

 remains tolerably constant, and is not so conspicuously 

 affected by the increase in food as one might expect. From 

 the recorded temperatures one sees the peculiar fluctuations 

 mentioned. To just what they are due it is impossible to 

 say. It is manifest that the normal temperature of these 

 animals, if we can speak of a normal temperature for animals 

 presenting such fluctuations, is about a degree or more, 

 Centigrade, higher than that of human beings. The animals 

 from which these charts were made were not inoculated, 

 nor were they subjected to any operative procedures what- 

 ever, the only deviations from normal conditions being the 

 variations in the daily amount of food given. 



In certain instances, however, there will be noticed a 

 constant tendency to diminution in weight, notwithstand- 

 ing the daily fluctuations, and after a time a condition of 

 extreme emaciation may be reached, the animal often being 

 reduced to from 50 to 60 per cent, of its original weight. 

 In other cases, after inoculations to which the animal is not 



