MICROCOCCUS GONORRHCEM 355 



individual cells that comprise the couplets are flattened and 

 separated by a narrow slit. At times the cocci are arranged 

 as tetrads. 



This organism cannot be grown at a temperature lower 

 than that of the human body, and cultures that have been 

 obtained by either of the favorable methods are said to 

 lose their vitality when kept at ordinary room-temperature 

 for about two days. 



It is killed in a few hours by drying. 



Cultures retain their vitality under favorable conditions 

 of nutrition, temperature, and moisture for from three to 

 four weeks. 



This organism is without pathogenic properties for 

 monkeys, dogs, and horses, as well as for the ordinary 

 smaller animals used for this purpose in the laboratory. 



In man typical gonorrhea has been produced on several 

 occasions by the introduction into the urethra of pure cul- 

 tures of this organism. 



In addition to its causal relation to specific urethritis, 

 it is the cause of gonorrheal prostatitis in man, of gonorrheal 

 proctitis in both sexes, and of gonorrheal inflammation of 

 the urethra, of Bartholin's glands, of the cervix uteri, and 

 of the vagina in women and young girls. It is etiologically 

 related to the specific conjunctivitis (ophthalmia neona- 

 torum) of young infants, and also occasionally to ophthalmia 

 in adults. 



Secondarily, it is concerned in specific inflammations of 

 the tubes and ovaries, of the lymphatics communicating 

 with the genitalia, of the serous surfaces of joints, and of 

 those of the heart, lungs, and abdominal cavity. 



Other species of micrococci have from time to time been 



