370 APPLICATION OF METHODS OF BACTERIOLOGY 



will be found in pure cultures in the blood and internal 

 viscera. 



When animals are inoculated with small doses (less than 

 1 c.c. of a bouillon culture) of this organism death may not 

 ensue, and only a local inflammatory reaction (abscess- 

 formation) may be set up. In these cases the animals are 

 usually protected from subsequent inoculation with doses 

 that would otherwise prove fatal. 



Most interesting in connection with pseudomonas ceru- 

 ginosa is the fact, as brought out in the experiments of 

 Bouchard, and of Charrin and others, that its products 

 possess the power of counteracting the pathogenic activities 

 of bacterium anthracis. That is to say, if an animal be 

 inoculated with a virulent anthrax culture, and soon after 

 be inoculated with a culture of pseudomonas wruginosa, the 

 fatal effects of the former inoculation may be prevented. 

 Emmerich and Low 1 are inclined to attribute this to the 

 direct bacteriolytic action of the enzymes upon the anthrax 

 bacteria introduced into the tissues. 



In the literature upon the green-producing organisms that 

 have been found in inflammatory conditions several varieties 

 believed to be distinct species have been described; but 

 when cultivated side by side their biological differences are 

 seen to be so slight as to render it probable that they are 

 but modifications of one and the same species. 



BACILLUS PESTIS, YERSIN, 1894. THE BACILLUS OF 

 BUBONIC PLAGUE. 



Before passing from the subject of suppuration it may 

 not be inappropriate to call attention to the light that 



1 Miinchener med. Wochenschrift, 1898, No. 40; Centralblatt fur Bakter- 

 iologie und Parasitenkunde, 1899, Abt. i, No. 1, p. 33. 



