TUBERCULOSIS. 267 



when the infection is general, i. e., when the process is 

 of the acute miliary type. This pathological-anatomical 

 alteration is best seen in the tissues of the liver and 

 spleen of these animals, where the condition is most 

 pronounced. 



In general, the tubercular lesions can be divided into 

 those of strictly focal character, i. e., the miliary and the 

 conglomerate tubercles, and those which are more diffuse 

 in their nature. The latter lesions, although of the same 

 fundamental nature as the miliary tubercles, are much 

 greater in extent and not so sharply circumscribed. 



These latter lesions play a greater role in the path- 

 ology of the disease than do the miliary nodules, although 

 it is to the presence of the miliary nodules that the dis- 

 ease owes its name. 



At autopsy the pathological manifestations of the dis- 

 ease are not infrequently seen to be confined to the seat 

 of inoculation and to the neighboring lymphatic glands. 

 These tissues will then present all the characteristics of 

 the tuberculous process in the stage of cheesy degenera- 

 tion. When the disease is general the degree of its ex- 

 tension varies. Sometimes the small gray nodules the 

 miliary tubercles are only to be seen with the naked 

 eye in the tissues of the liver and spleen. Again, they 

 may invade the lungs, and commonly they are distrib- 

 uted over the serous membranes of the intestines, the 

 lungs, the heart, and the brain. These simple gray 

 nodules, as seen by the naked eye, vary in size from 

 that of a pin-point to that of a hempseed, and as a rule 

 are, in this stage, the result of the fusion of two or more 

 smaller miliary foci. Though the two terms, " miliary " 

 and "conglomerate/ 7 exist for the description of the 

 macroscopic appearance of these nodules, yet it is very 



