432 BACTERIOLOGY. 



claimed that a sort of protection against certain specific 

 infections can also be afforded to animals by the injection 

 into them of cultures of entirely different species of 

 bacteria, or their products, and that in some cases these 

 are not of necessity of the disease-producing variety. 

 For instance, Emmerich and Mattei 1 claim to have 

 rendered rabbits insusceptible to anthrax through in- 

 jections into them of cultures of the streptococcus of 

 erysipelas. 



This, they claim, is not due to any antagonism 

 between the organisms themselves, for in culture experi- 

 ments the two organisms grew well together, without 

 any alteration in their pathogenic properties, but rather 

 to the production of a tissue-change by which resistance 

 to the inroads of the virulent bacilli was established. 

 Emmerich and Mattei interpret this " reactive tissue- 

 change " as a power acquired by the integral cells of the 

 body, through the influence of a stimulus, of generating 

 a product that is detrimental to the pathogenic activity 

 of the anthrax bacilli. 



P.awlowsky, 2 who obtained similar results from the 

 introduction into the animal of cultures of the bacillus 

 prodigiosus, of staphylococcus pyogenes aureus, and of the 

 micrococcus lanceolatus, believes them to be due to the 

 induction of increased energy on the part of the wander- 

 ing cells, preparing them thus for the difficult task of 

 destroying the more virulent organisms with which the 

 animal is subsequently to be inoculated. 



The experiments of G. and F. Klemperer 3 upon acute 

 fibrinous pneumonia, though too limited in extent to 



1 Emmerich und Mattei : Fortschritte der Medizin, 1887, p. 653. 



2 Pawlowski : Virchow's Arch., vol. cviii. p. 494. 



a G. and F. Klemperer : Berliner klin. Wochenschr., 1891, Nos. 34 and 35. 



