454 APPLICATION OF METHODS OF BACTERIOLOGY 



fungus in the tissues. We have also observed this mode 

 of development by Bacillus tuberculosis. (Figs. 77 and 78.) 



It is important to note the difference between the results 

 of intravenous inoculation of rabbits with bacillus tuber- 

 culosis arid with the organisms under consideration. When 

 bacillus tuberculosis is employed, the lungs, as well as the 

 kidneys, are always involved, while with the grass bacillus 

 II, the timothy bacillus, and the butter bacillus, involve- 

 ment of the lungs, in our experiments, has been the exception 

 rather than the rule. 



Another point of interest is the lack of tendency on the 

 part of the non-tuberculous process to progress or become 

 disseminated. 



That the members of this group are botanically related 

 to bacillus tuberculosis there seems little room for doubt; 

 but from personal study and from available evidence from 

 other sources it appears unlikely that they are, except 

 experimentally, concerned in disease production or that they 

 are of importance to either human or animal pathology. 1 



In the microscopic examination, particularly of urine, 

 of secretions from about the anus, rectum, and genitalia, 

 and of butter, it is manifestly of importance to bear in mind 

 the existence of this confusing group, for it is in such secre- 

 tions and substances that its members are most often en- 

 countered. The smegma bacillus and the butter bacillus 

 are especially liable to lead one into error of diagnosis. 

 This is less apt to be the case with the comparatively rare 

 lepra bacillus. 



1 For the literature on "acid-proof" bacilli, see Cowie, Journal of Experi- 

 mental Medicine, 1900, v, 205. 



