590 APPLICATION OF METHODS OF BACTERIOLOGY 



which the circulation is slowest. They are uniformly dis- 

 tributed through the spleen. The glomeruli of the kidneys 

 and the capillaries of the lungs are frequently packed with 

 them. The capillaries of the liver contain them in large 

 numbers. (Fig. 99.) Hemorrhages, probably due to 

 rupture of capillaries by the mechanical pressure of the 

 bacteria which are developing within them, not uncommonly 

 occur. When these occur in the mucous membranes of the 

 alimentary tract the blood may escape through the mouth 



Bacterium anthracis in liver of mouse. X about 450 diameters. Bacteria 

 stained by Gram's method; tissue stained with Bismarck-brown. 



or anus; when in the kidneys, through the uriniferous 

 tubules. 



Cultures from the different organs or from the edematous 

 fluid about the point of inoculation result in growth of 

 bacterium anthracis. 



The amphibia, dogs, and the majority of birds are not 

 susceptible to this disease. Rats are difficult to infect. 

 Rabbits, guinea-pigs, white mice, gray house-mice, sheep, 

 and cattle are susceptible. Infection may occur either 



