IMMUNITY. 379 



flammation, and hence upon a stimulation of 

 the cell territories already seized by the bac- 

 teria or involved in the invasion. 



After it had been discovered by Nageli, 

 Pasteur and Koch, and still more precisely by 

 Emmerich, Freudenreich, Woodhead, Wood 

 and Hueppe that some pathogenic bacteria are 

 destroyed in cultures by saprophytic bacteria, 

 the attempt was made to effect a cure by in- 

 corporating such saprophytes into the body of 

 previously infected animals. Clinical experi- 

 ence afforded some justification for this pro- 

 cedure, as for instance in the observations that 

 cancerous tumors degenerate if the bacterial 

 disease of erysipelas makes its appearance at 

 the diseased locality, and that the sickening 

 odor of a cancer may abate and even cease 

 when bandages wet with a lactic acid fermen- 

 tation are applied. Cantani, by his use against 

 tuberculosis of bacteria of putrefaction was the 

 first to employ such a " bacterio-therapy." 

 Animal anthrax was more satisfactorily com- 

 bated by Emmerich, di Mattei and Paul- 

 owski, by use of the living bacteria of erysipe- 

 las or the microbe of the bleeding-host (B. 

 prodigiosus), and by Bouchard, Woodhead and 

 Wood by use of the bacteria of green pus. Up 

 to the present, therefore, we have attempted to 

 imitate two natural methods of producing im- 



