496 PROCESSES INFERRED FROM INDIRECT OBSERVATION 



ties are more or less enlarged and the development of the sexual organs 

 may be exaggerated. These latter symptoms are, however, more 

 commonly displayed in the second type of anomalous development of 

 hypophyseal origin, that afforded by the instances of Acromegaly. In 

 these individuals the symptoms do not usually supervene until maturity 

 has been attained and the epiphyses of the bones have hardened so that 

 growth in length is no longer possible. The extremities of the bones 

 become enlarged so that the phalanges of the fingers, for example, are 



FIG. 36. Acromegalic gigantism. Height, 6 ft. 1 in.; weight, 247 pounds. 

 (After Gushing.) 



spatula-shaped. The bodily weight becomes excessive, so that these 

 individuals also, especially if above the average in stature, may from 

 time to time be exhibited as giants. The features are coarsened and 

 thickened and there is an extraordinary development of epithelial 

 tissue and of epithelial appendages. The development of hair all over 

 the body may be so excessive as to lend to the individual, especially 

 when conjoined with thickened and distorted features and massive 

 development of the* jaw, a truly simian appearance (Fig. 36). Close 



