Biological Therapy 



113 



drawn. The plasma portion of the blood is separated from 

 the corpuscles and fibrin, rendered sterile and a preserva- 

 tive added. This is now ready for a test to determine the 

 potency of the serum which varies somewhat depending upon 

 the identity of the product. Each product is subjected to the 

 tests which are recognized as most satisfactory for deter- 

 mining the potency of the particular type of serum, whether 

 this be the agglutination, complement fixation, or animal 

 inoculation test. After the product has been found fully 

 potent it is subjected to a series of exacting tests to deter- 

 mine its freedom from contamination. 



Between each bleeding the producing horses are in- 

 jected with massive doses of the specific antigen which 

 causes the cells to continue functioning thus maintaining the 

 high antibody content of the serum. The bacteria contained 

 in the antigen used for the production of Pitman-Moore Im- 

 mune Sera are obtained in a special manner. The stock 

 cultures used for this purpose are carefully selected strains 

 originating in many parts of the country from acute out- 

 breaks of the disease for which the serum is recommended. 

 Cultures are never used until their antigenic ability has been 

 proven, after which special scientific care, such as very 

 frequent passaging through laboratory animals, is exercised 

 to insure the retention of these antigenic activities. These 

 are some of the factors which account for the uniformly 

 good results obtained with Pitman-Moore immune sera. 



Among the sera prepared in the above manner are the 

 following: 



Tetanus Antitoxin. 

 Anti-Calf Scour Serum. 

 Canine Anti-Distemper Serum. . , 



Anti-Influenza Serum (Equine). 

 Anti-Distemper Serum (Equine). 

 Anti-Blackleg Serum. 

 Anti-Streptococcic Serum (Equine). 

 Anti-Hemorrhagic Septicemia Serum (Swine). 

 Anti-Hemorrhagic Septicemia Serum (Cattle). 

 Anti-Hemorrhagic Septicemia Serum (Equine). 

 Anti-Snuffles Serum (Rabbits). 

 Anti-Mixed Infection Serum (Swine). 



The use of each of these serums is described under the 

 disease for which it is recommended. 



