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Biological Therapy 



GENERAL CONSIDERATIONS REGARDING IMMUNE 



SERA 



Results following the use of these are generally very- 

 satisfactory. To insure best results the following factors 

 should be observed. 



1. Diagnosis must be correct. 



2. The specific serum prepared for the disease in ques- 

 tion must be used. 



3. Large doses should be the rule. Serum should be 

 used early, and whenever possible, intravenously. 



4. Immunity conferred by immune sera is passive in 

 type and of relatively short duration. After the animal has 

 recovered, its passive immunity should be reinforced by the 

 use of other biologies which confer active immunity. 



PITMAN-MOORE BACTERINS 



Realizing that the field results obtained with bacterins 

 are directly dependent upon several factors connected with 

 their production, every safeguard known to modern science 

 is exercised in the production of these products. Every cul- 

 ture used has been carefully selected from a virulent case of 

 the disease which the bacterin is intended to combat. Each 

 is subjected to the most painstaking examination to prove its 

 identity, but even when this is established the culture is not 

 used until its antigenic ability has been prpven by inocula- 

 tions into laboratory animals. The virulence of our stock 

 cultures is maintained by frequent animal passages and the 

 cultures are constantly studied to maintain purity of growth 

 and retention of their antigenic activities. The media upon 

 which they are grown is given careful consideration and 

 every step used in the production of bacterins is closely 

 guarded. 



All Pitman-Moore bacterins are sterilized by chemicals 

 rather than by heat, resulting in the retention of the anti- 

 genic substances which are destroyed in bacterins sterilized 

 by heat. The preservative is added in such a manner that 

 burning of the bacteria is prevented and autolysis is mini- 

 mized. Each lot is standardized so that the count given 

 on the label is actually contained in the product. 



