Biological Therapy 



119 



PREVENTION 



Since no known method of treating affected animals is 

 effective our efforts must be centered on prevention. In 

 this respect disinfection and isolation are important factors. 

 The isolation of all animals with vaginal discharges and 

 the disinfection of all contaminated material is most ad- 

 visable. Uterine douches in the treatment of metritis and 

 retained placenta following abortion are sometimes bene- 

 ficial. However strong antiseptic solutions are inadvisable 

 for this purpose since they are generally devoid of results 

 and are conducive to tissue destruction. Metritis bacterin 

 which contains the organisms associated with these cases 

 of metritis offers the best possibility of controlling these 

 sequelae. 



Killed suspensions of B. abortus have been used in an 

 effort to immunize against infectious abortion. In all care- 

 fully controlled experiments with this product, the results 

 have shown that little if any immunity resulted. 



Many eminent authorities on abortion have investigated 

 the ability of living B. abortus to immunize against this 

 disease. These investigators are agreed that the rate of 

 abortion following the use of living cultures (vaccine) is 

 materially reduced and that this product offers the most 

 rational method of immunization. This conclusion has been 

 reached by McFadyean, Stockman and Bland of England, 

 by Zwick, Zeller, Krage and Gminder of the Imperial Bureau 

 of Health, Berlin, as well as by Hadley and numerous other 

 investigators in this country. In view of the proven value 

 of this product as shown by such authorities there is now 

 available 



PITMAN-MOORE ABORTION VACCINE (BOVINE) 



This product contains living B. abortus (Bang) sus- 

 pended in a vehicle which is particularly favorable for pre- 

 serving both the viability and the antigenic properties of the 

 organisms. The medium in which the organisms are sus- 

 pended eliminates the danger of lost viability, thus insuring 

 the greatest possible amount of antibody production follow- 

 ing injection. The bacterial count is carefully adjusted to 

 permit of full antibody production without the increased 

 danger of abscess formation encountered in bacterial anti- 

 gens of excessive protein content. 



