122 Biological Therapy 



PITMAN-MOOEE BLACKLEG FILTRATE 



Strains of the "blackleg bacillus" which have proven 

 their antigenic ability are grown in specially prepared media 

 until this is thoroughly saturated with the desired antigen. 

 This is then filtered through Berkefeldt filters to insure its 

 freedom from all bacteria after which a suitable preservative 

 is added. The finished product is next subjected to several 

 tests to determine its potency or ability to confer immunity 

 on calves, after which it is subjected to the most rigid sci- 

 entific tests to determine its sterility. It is impossible for 

 such a product to cause disease in the animals into which it 

 is injected. 



DOSE. Five c.c. injected subcutaneously. After calves 

 are immunized against blackleg, a period of four to twelve 

 days elapses before immunity is established. This point 

 should be considered in treating calves in infected herds 

 since animals treated during the period of incubation may 

 not be protected. 



TREATMENT. For this purpose Anti-Blackleg Serum 

 is available. This is made from the blood of horses as de- 

 scribed on page 111. When this product is used in the early 

 stages of the disease, particularly before the temperature 

 drops, it results in the recovery of many affected animals. 

 It is advised that large doses (200 to 500 c.c.) be injected 

 intravenously and that this be repeated if necessary. 



The immunity conferred by Anti-Blackleg Serum is of 

 exceedingly short duration (ten to twenty days), hence the 

 product should he used only in affected cattle and should he followed 

 in ten to twelve days hy five cc. of Blackleg Filtrate. 



In herds where blackleg is prevailing, suspicious cases 

 should receive anti-blackleg serum in preference to filtrate 

 on account of the time required for the filtrate to produce 

 immunity, whereas by the use of serum protection is ob- 

 tained almost immediately. 



Canine Distemper 



This is an acute infectious disease of dogs, not trans- 

 missible to other species. It is attended by high mortality. 

 It is particularly a disease of the young and few puppies 

 reach maturity without being affected. 



