124 Biological Therapy 



upon, first, its early use, and secondly, upon large, frequently 

 repeated doses. Small doses in severe cases offer little hope 

 for success. Large doses, 30 to 100 c.c. repeated as necessary 

 in developing cases, is our most rational treatment and is 

 being used by many of the best canine specialists with ex- 

 cellent results. The dosage may be decreased approximately 

 one-third if intraperitoneal injections are used. 



The treatment of the intestinal type of canine distemper 

 has always proved extremely difficult since cases have been 

 most refractory to treatment and the mortality exceedingly 

 high. Considerable success in treating this type is now 

 being obtained by the intraperitoneal injections of canine 

 anti-distemper serum and by high intestinal enemas of nor- 

 mal saline solution followed in a few hours with a rectal 

 injection of canine anti-distemper serum, 20 to 50 c.c. 



PREVENTION. For this purpose both canine anti-dis- 

 temper serum and canine distemper bacterin are used. 



The bacterin should be administered in three injections 

 of two c.c. each at intervals of five to seven days. This 

 form of immunization is being successfully used in many 

 places where previously the disease claimed a heavy toll. 



Canine anti-distemper serum when used for prophy- 

 laxis should be used in ten to fifteen c.c. doses. Immunity 

 conferred in this manner should not be depended upon after 

 three weeks but should be prolonged either by repeated in- 

 jections of serum or by the use of bacterin. 



The ability of Pitman-Moore Canine Anti-Distemper 

 Serum and Canine Distemper Bacterin to protect against 

 distemper has been conclusively proven in many hospitals. 

 It has been a common experience in many such institutions 

 that patients admitted for minor operations or treatment 

 would contract distemper while on the premises or shortly 

 after returning home. Several such hospitals have com- 

 pletely eliminated this trouble by administering ten to fifteen 

 c.c. of canine anti-distemper serum or three injections of 

 bacterin to every patient admitted. In hospitals and ken- 

 nels this treatment should not be used to the exclusion of 

 sanitation and disinfection. When these precautions are 

 constantly and thoroughly executed the possibilities of bio- 

 logical control of the disease are greatly enhanced. 



