132 



Biological Therapy 



forty per cent, staphylococcus thirty per cent and B. equi- 

 septicum thirty per cent. All organisms used in preparing 

 the product have been isolated from acute cases of influenza. 

 The dose is two c.c. which contains sixty billion organisms. 

 To obtain best results three injections should be given at 

 intervals of three to seven days. 



'*Flu" in Swine 



The existence of so-called "flu" as a specific disease of 

 swine has never been definitely established. 'Most investiga- 

 tors are of the opinion that this condition is a peracute form 

 of hemorrhagic septicemia, since the symptoms and lesions 

 of both are identical. Murray isolated a coccus from these 

 cases but other investigators have obtained only B. suisep- 

 ticum in pure culture. Cases of so-called "flu" respond in a 

 satisfactory manner to hemorrhagic septicemia bacterin or 

 anti-hemorrhagic septicemia serum, therefore it is recom- 

 mended that the treatments and preventive measures de- 

 scribed under Hemorrhagic Septicemia be used in these 

 cases. 



Fowl Cholera 



This, the most serious of all diseases of fowls, is an acute 

 septicemia to which all domesticated birds are susceptible. 

 The disease is highly infectious and is prevalent in all parts 

 of the country. Its introduction into a flock is followed by 

 a mortality ranging from 90 to 100 per cent. 



ETIOLOGY. Fowl cholera is caused by a member of the 

 hemorrhagic septicemia group, B. avisepticum. The organ- 

 ism usually enters the body by way of the digestive tract 

 although it is believed that the mucous membranes some- 

 times act as a portal of entrance. B. avisepticum is readily 

 isolated from the blood and organs of affected, birds. 



SYMPTOMS. These may be entirely absent in which 

 case birds are found dead on or near the roost without pre- 

 vious evidence of sickness. The period of incubation is 

 from 18 to 72 hours and death ordinarily intervenes after but 

 a few hours of apparent sickness. In some flocks the last 

 birds to be affected show some evidence of increased resist- 

 ance in which case the acute lesions subside and there is a 

 marked tendency toward chronicity. 



