144 



Biological Therapy 



the treatment of affected animals. This serum may be in- 

 jected subcutaneously or intramuscularly. The dose is from 

 thirty c.c. upwards, depending upon the size and condition 

 of the animal, and may be repeated each twelve hours, if 

 indicated, until temperature and acute symptoms subside. 

 In acute cases where the diagnosis is correct the results fol- 

 lowing the use of this product are both safe and gratifying. 

 Its injection is frequently followed by a drop of several de- 

 grees in temperature within twelve hours. The product is 

 absorbed rapidly and its action is begun almost instantan- 

 eously. 



HEMORRHAGIC SEPTICEMIA BACTERIN is used ex- 

 tensively for therapeutic purposes where the value of the 

 animals will not justify the use of anti-hemorrhagic septi- 

 cemia serum. When used for therapeutic purposes at least 

 two c.c. should constitute a dose. This may bs repeated ad- 

 vantageously in acute cases each twenty-four hours until the 

 animal shows marked improvement. In many cases a rapid 

 drop in temperature and a general improvement of the pa- 

 tient follows two or three injections. 



In addition to biological treatment as outlined above, 

 the rations of the affected herd should be very carefully in- 

 vestigated. It is imperative that the feeding of highly con- 

 centrated food or food rich in nitrogenous material be 

 eliminated. For this reason it is recommended that all 

 corn and tankage be withheld and that the animals be lightly 

 fed upon soft feed. The sanitary conditions should be care- 

 fully investigated and the quarters should be bright, dry and 

 free from drafts. Prolonged cold or wet weather is fre- 

 quently the factor responsible for an outbreak of hemor- 

 rhagic septicemia. Therefore protection from exposure re- 

 quires considerable attention. 



PREVENTION. Anti-Hemorrhagic Septicemia Serum 

 will confer passive immunity of three to six weeks' dura- 

 tion. It is valuable in exposed animals since its protective 

 action is obtained almost immediately after injection. 

 Twenty to thirty c.c. constitute a protective dose. The injec- 

 tions may be made subcutaneously or intramuscularly, but 

 intravenous injections produce quickest results. 



Hemorrhagic Septicemia Bacterin. At least two, and 

 preferably three, injections of two c.c. each should be admin- 

 istered at intervals of five to seven days. The exact duration 

 of immunity conferred varies considerably in different indi- 

 viduals but is ordinarily of from one to six months duration. 



