Biological Therapy 



147 



TRANSMISSION. The disease spreads rapidly from 

 one animal to another. The material sneezed or discharged 

 from the nostrils is undoubtedly the greatest factor in the 

 transmission of the disease bo^th as a droplet infection and 

 by contaminating the bedding and feed used by other ani- 

 mals. Attendants going from one animal to another are 

 frequently responsible for spreading the disease. 



If pyogenic bacteria cause a secondary invasion, ab- 

 scesses throughout the various organs are found. 



TREATMENT. Medicinal treatment is of no value, 

 while sanitation is of the greatest importance. The cages 

 or pens should be frequently disinfected and kept scrupu- 

 lously clean. All sick or suspicious animals should be iso- 

 lated. Avoid exposure to cold and dampness and allow all 

 the sunshine possible. 



Best results from the treatment of affected animals have 

 been obtained by the use of Anti-Hemorrhaglc Septicemia 

 Serum (Snuffles Serum). Quickest results follow intraven- 

 ous injections of this product in 3 c.c. doses. For this pur- 

 pose the marginal ear vein is best adapted. If used subcu- 

 taneously, five to ten mils should be given. Very small ani- 

 mals should receive one-half the amount recommended for 

 adult animals. Best results will follow the frequent admin- 

 istration of medium sized doses rather than maximum doses 

 at infrequent intervals. 



PREVENTION. Snuffles Mixed Bacterin should be 

 used upon the healthy exposed animals. This product con- 

 tains B. cuniculisepticum, streptococci and staphylococci in 

 well balanced proportions. Each dose of two c.c. contains 

 six billion killed organisms, which have been isolated from 

 cases of snuffles in all parts of the country, making this a 

 truly polyvalent bacterin. Although good results frequently 

 follow one injection best and most lasting immunity follows 

 the full treatment of three injections at intervals of five to 

 seven days. 



Anti-Hemorrhagic Septicemia (Snuffles) Serum may 

 also be used for prophylaxis. The protection afforded by 

 such treatment is almost immediate and an immunity of 

 several weeks is conferred. Five c.c. should be administered 

 intravenously or subcutaneously. 



